Prospective Observational Study Regarding the Determinants of Functional Disability and Quality of Life in Patients Recovering From Severe Acute Cardiac or Respiratory Failure Considered for Mechanical Cardiorespiratory Support (CLEVERER)
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
To observe and identify determinants of recovery from intensive care unit-acquired weakness (ICUAW) following a severe cardiorespiratory failure requiring extra-corporeal membrane oxygenation (ECMO). Additionally, to discover the effects of ICUAW on physical function and health-related quality of life (HRQoL) after critical illness. CLEVERER is a clinical observational pilot study.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Above the age of 18
• Adults with severe cardio-respiratory failure requiring ECMO.
• Adults who have had personal and professional consultees agree to enrol them in the trial.
Locations
Other Locations
United Kingdom
St Bartholomew's hospital (Barts NHS trust)
RECRUITING
London
Contact Information
Primary
Mark Griffiths, PhD FRCP
Mark.griffiths@bartshealth.nhs.uk
07875999126
Backup
Ashley Thomas, MSc
ashleythomas@nhs.net
07597875857
Time Frame
Start Date: 2019-04-09
Estimated Completion Date: 2025-09-26
Participants
Target number of participants: 100
Treatments
ICUAW ECMO group
The physical and psychological effects of ICUAW on patients receiving extracorporeal membrane oxygenation for severe cardiorespiratory failure will be observed. Physical function and HRQoL will be analysed and correlated with RFcsa. Additionally, biological markers will be used to understand molecular and genomic profiles.
Related Therapeutic Areas
Sponsors
Collaborators: Queen Mary University of London
Leads: Barts & The London NHS Trust